Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: " The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus. | Kahlenberg and Kaplan Arthritis Research Therapy 2011 13 203 http arthritis-research.eom content 13 1 203 REVIEW The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus J Michelle Kahlenberg and Mariana J Kaplan Abstract Patients with systemic lupus erythematosus have up to a 50-fold increased risk of developing atherosclerotic cardiovascular disease. Recent advances in the etiology of vascular damage in this disease stress the interplay of lupus-specific inflammatory factors with traditional cardiac risk factors leading to increased endothelial damage. This review analyzes the putative role that immune dysregulation and lupus-specific factors may play in the pathogenesis of premature vascular damage in this disease. The potential role of various cytokines in particular type I interferons in the development of accelerated atherosclerosis is examined. Potential therapeutic targets are discussed. Epidemiology of premature vascular damage in systemic lupus erythematosus Systemic lupus erythematosus SLE is an autoimmune disease with heterogeneous manifestations including internal organ damage which can result in severe morbidity and even death and often requires aggressive immunosuppressive treatment. More than 30 years ago a bimodal peak in mortality was described in lupus patients with late increases in death commonly seen as secondary to premature cardiovascular disease CVD 1 . Indeed this enhanced atherosclerotic risk increases with each year of disease duration. This is especially the case in young females with SLE where the CVD risk can be up to 50-fold higher than in age-matched controls 2 3 . While traditional Framingham risk factors likely contribute to CVD in SLE they cannot fully account for the increased risk. Instead the pathogenesis of premature CVD in SLE may rely on factors unique to the disease itself 4 . Correspondence makaplan@umich.edu Division of Rheumatology Department of Internal Medicine University of Michigan .