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Báo cáo y học: "Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: A randomized controlled trial"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: A randomized controlled trial. | Duiverman et al. Respiratory Research 2011 12 112 http respiratory-research.eom content 12 1 112 RESPIRATORY RESEARCH RESEARCH Open Access Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients A randomized controlled trial KAsiriolzo I Pil ii arm f l 1 2lm H n R yA omr to3 RIsiHHor2 II iHifh KA nnk4 C 7ii Icfr 5 Ml lih A l l ICorcTíonc1 Malleke L uuiveillldll JUHdn B vvempe Gerrie Bladder Judith M vunk Jan G Zljistld Huib AM Keistjeiis and Peter J Wijkstra1 2 Abstract Background THe use of noninvdsive intermittent positive pressure ventilation NIPPV in chronic obstructive pulmonary disease COPD patients with chronic Hypercapnic respiratory failure remains controversial as long-term data are almost lacking. The aim was to compare the outcome of 2-year Home-based nocturnal NIPPV in addition to rehabilitation NIPPV PR with rehabilitation alone PR in COPD patients with chronic hypercapnic respiratory failure. Methods Sixty-six patients could be analyzed for the two-year home-based follow-up period. Differences in change between the NIPPV PR and PR group were assessed by a linear mixed effects model with a random effect on the intercept and adjustment for baseline values. The primary outcome was health-related quality of life HRQoL secondary outcomes were mood state dyspnea gas exchange functional status pulmonary function and exacerbation frequency. Results Although the addition of NIPPV did not significantly improve the Chronic Respiratory Questionnaire compared to rehabilitation alone mean difference in change between groups -1.3 points 95 CI -9.7 to 7.4 the addition of NIPPV did improve HRQoL assessed with the Maugeri Respiratory Failure questionnaire -13.4 -22.7 to -4.2 p 0.005 mood state Hospital Anxiety and Depression scale -4.0 points -7.8 to 0.0 p 0.05 dyspnea Medical Research Council -0.4 points -0.8 to -0.0 p 0.05 daytime arterial blood gases PaCO2 -0.4 kPa -0.8 to -0.2 p 0.01 PaO2 0.8