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Báo cáo y học: "Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:""Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. | Respiratory Research BioMed Central Open Access Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers Alireza Sadeghnejad 1 Jill A Ohar1 Siqun L Zheng1 David A Sterling2 Gregory A Hawkins1 Deborah A Meyers1 and Eugene R Bleecker 1 Address 1Center for Human Genomics and Department of Medicine and Pediatrics Wake Forest University School of Medicine Winston-Salem North Carolina USA and 2School of Public Health Saint Louis University St. Louis Missouri USA Email Alireza Sadeghnejad - anejad@wfubmc.edu Jill A Ohar - johar@wfubmc.edu Siqun L Zheng - szheng@wfubmc.edu David A Sterling - sterling@slu.edu Gregory A Hawkins - ghawkins@wfubmc.edu Deborah A Meyers - dmeyers@wfubmc.edu Eugene R Bleecker - ebleeck@wfubmc.edu Corresponding authors Published 12 March 2009 Received 18 August 2008 Respiratory Research 2009 10 21 doi l0.ll86 l465-992l-l0-2l Accepted l2 March 2009 This article is available from http respiratory-research.cOm content l0 l 2l 2009 Sadeghnejad et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however has not been investigated in the population susceptible to COPD long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers. Methods Caucasian subjects at least 50 year old who smoked 20 pack-years n 880 were genotyped for 25 single nucleotide polymorphisms SNPs in ADAM33. COPD was defined as an FEVl FVC ratio 70 and percent-predicted pp FEVl 75 n 287 . The control group had an FEVl FVC ratio 70 and ppFEVI 80 n 3ll despite 20 pack years of .