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Báo cáo y học: "The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis. | Mjaavatten et al. Arthritis Research Therapy 2010 12 R76 http arthritis-research.eom content 12 3 R76 RESEARCH ARTICLE Open Access The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor a longitudinal study of 376 patients with very early undifferentiated arthritis Maria D Mjaavatten 1 Désirée van der Heijde1 2 Till Uhlig1 Anne J Haugen3 Halvor Nygaard4 Goran Sidenvall5 Knut Helgetveit6 and Tore K Kvien1 Abstract Introduction We wanted to assess the importance of the levels of anti-citrullinated peptide antibody anti-CCP and immunoglobulin M IgM rheumatoid factor RF in predicting development of persistent arthritis from undifferentiated arthritis UA and to investigate whether there is an added predictive value for persistent arthritis in testing for both anti-CCP and IgM RF. Methods Patients with UA exclusion of definite non-rheumatoid arthritis RA diagnoses included in the Norwegian very early arthritis clinic were assessed for development of persistent arthritic disease. The effect of antibody level on the likelihood of persistent arthritis was investigated and the sensitivity and specificity for persistent arthritis for anti-CCP and IgM RF separately and combined was determined. Results A total of 376 UA patients were included median arthritis duration 32 days . 59 15.7 patients were IgM RF positive and 62 16.5 anti-CCP positive. One hundred seventy-four 46.3 had persistent disease after one year. Overlap of anti-CCP and IgM RF positivity was 58 . Sensitivity specificity for persistent arthritis was 28 95 for IgM RF alone 30 95 for anti-CCP alone and 37 92 for positivity of both anti-CCP and IgM RF. The likelihood for persistent disease increased with increasing levels of both anti-CCP and IgM RF. Conclusions The likelihood of developing persistent arthritis in UA patients increases with the level of anti-CCP and IgM RF. Testing both anti-CCP and IgM RF has added predictive .