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Báo cáo y học: "TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies. | van Nies et al. Arthritis Research Therapy 2010 12 R38 http arthritis-research.eom content 12 2 R38 RESEARCH ARTICLE Open Access TRAF1 C5 polymorphism is not associated with increased mortality in rheumatoid arthritis two large longitudinal studies Jessica AB van Nies1 Rute B Marques1 Stella Trompet2 3 Zuzana de Jong1 Fina AS Kurreeman1 Rene EM Toes1 J Wouter Jukema2 Tom WJ Huizinga1 Annette HM van der Helm-van Mil1 Abstract Introduction Recently an association between a genetic variation in TRAF1 C5 and mortality from sepsis or cancer was found in rheumatoid arthritis RA . The most prevalent cause of death cardiovascular disease may have been missed in that study since patients were enrolled at an advanced disease stage. Therefore we used an inception cohort of RA patients to investigate the association between TRAF1 C5 and cardiovascular mortality and replicate the findings on all-cause mortality. As TRAF1 C5 associated mortality may not be restricted to RA we also studied a large cohort of non-RA patients. Methods 615 RA patients from the Leiden Early Arthritis Clinic EAC mean follow-up 7.6 years were genotyped for rs10818488. In addition 5634 persons enrolled in the PROspective Study of Pravastatin in the Elderly at Risk mean follow-up 3.2 years were genotyped for rs2416808 R2 0.99 with rs10818488 . The life death status was determined and for the deceased persons the cause of death was ascertained. Cox proportional hazards and regression models were used to assess hazard ratios HR and 95 confidence intervals CI . Results Seventy-seven RA patients died. The main death causes in RA patients were cardiovascular diseases 37.7 cancer 28.6 and death due to infections 9.1 . No association was observed between the rs10818488 susceptible genotype AA and cardiovascular mortality HR 1.08 95 CI 0.54 to 2.15 and all-cause mortality HR 0.81 95 CI 0.27 to 2.43 . Similar findings were observed for rs2416808 susceptible genotype GG in the non-RA cohort HR 0.99 95 CI 0.79 to .