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Báo cáo y học: " The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children. | Alcântara-Neves et al. Respiratory Research 2010 11 114 http respiratory-research.eom content 11 1 114 RESPIRATORY RESEARCH RESEARCH Open Access The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and or atopy in preschool-aged Brazilian children 1 1 1 2 Neuza M Alcântara-Neves Samuel J Badaró Mariese CA dos Santos Lain Pontes-de-Carvalho Mauricio L Barreto3 Abstract Background The elucidation of factors that trigger the development of transient wheezing in early childhood may be an important step toward understanding the pathogenesis of asthma and other allergic diseases later in life. Transient wheezing has been mainly attributed to viral infections although sensitisation to aeroallergens and food allergens may occur at an early age. In developing countries intestinal helminthic infections have also been associated with allergy or atopy-related disorders. Objective The aim of this study was to explore the association of Trichuris trichiura and Ascaris lumbricoides infections with wheezing and atopy in early childhood. Study design A cross-sectional study using a Portuguese-language ISAAC phase I questionnaire adapted for preschool-aged children nested in a cohort study of childhood diarrhoea was conducted on 682 children. Two faecal samples per child were examined for the presence of intestinal helminthic infection. IgE antibodies against three allergenic preparations Dermatophagoides pteronyssinus Blomia tropicalis and common child food as well as against A. lumbricoides antigens were measured in a sub-sample of these children whose parents allowed the procedure. Atopy was defined by the presence of levels of serum IgE antibodies 0.35 kU L against at least one of the three tested allergenic preparations. Results Active T. trichiura infection but not A. lumbricoides infection was positively associated with wheezing in the total studied children population adjusted OR 2.60 CI 1.54 4.38 .