tailieunhanh - Báo cáo y học: "Directed cell migration in the presence of obstacles"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Directed cell migration in the presence of obstacles | Theoretical Biology and Medical Modelling Research Directed cell migration in the presence of obstacles Ramon Grima 1 2 BioMed Central Open Access Address Indiana University School of Informatics and Biocomplexity Institute Bloomington IN 47406 USA and institute for Mathematical Sciences Imperial College London SW7 2PG UK Email Ramon Grima - Corresponding author Published 16 January 2007 Received 2 October 2006 Theoretical Biology and Medical Modelling 2007 4 2 doi 1742-4682-4-2 Accepted 16 January 2007 This article is available from http content 4 l 2 2007 Grima licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chemotactic movement is a common feature of many cells and microscopic organisms. In vivo chemotactic cells have to follow a chemotactic gradient and simultaneously avoid the numerous obstacles present in their migratory path towards the chemotactic source. It is not clear how cells detect and avoid obstacles in particular whether they need a specialized biological mechanism to do so. Results We propose that cells can sense the presence of obstacles and avoid them because obstacles interfere with the chemical field. We build a model to test this hypothesis and find that this naturally enables efficient at-a-distance sensing to be achieved with no need for a specific and active obstacle-sensing mechanism. We find that i the efficiency of obstacle avoidance depends strongly on whether the chemotactic chemical reacts or remains unabsorbed at the obstacle surface. In particular it is found that chemotactic cells generally avoid absorbing barriers much more easily than .

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