tailieunhanh - Báo cáo y học: "How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings. | Gonda et al. Annals of General Psychiatry 2010 9 21 http content 9 1 21 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele Equivocal preliminary findings zxX X I -X X X z-l -X 1 2 x-x f- 4 XX X 1X X zx f- I c I Ix-x ZX I I I -X lz I r 3 ỉ r 14 X X X D I fx x-xx zx z2 A x-x z-l X tr I -XI 1 lz4 I_I -X S zx zx c A Izi r lz I 15 r X ỉ r zzxx ỉ D -X zx z-l X Ỉ1 Xenia Gonda Konstantinos N rountoulaKis zoltan Riumer Andras LasziK Hagop S AKisKai Gyorgy Bagdy Abstract Objective The s allele of the 5-hydroxytryptamine transporter-linked promoter region 5-HTTLPR polymorphism of the serotonin transporter gene has been found to be associated with neuroticism-related traits affective temperaments and response to selective serotonin reuptake inhibitor SSRI treatment. The aim of the current study was to develop a psychometric tool that could at least partially substitute for laboratory testing and could predict the presence of the s allele. Methods The study included 138 women of Caucasian origin mean years old. All subjects completed the Hungarian standardised version of the Temperament Evaluation of the Memphis Pisa Paris and San Diego Autoquestionnaire TEMPS-A instrument and were genotyped for 5-HTTLPR using PCR. The statistical analysis included the calculation of the Index of Discrimination D Discriminant Function Analysis creation of scales on the basis of the above and then item analysis and calculation of sensitivity and specificity. Results Four indices were eventually developed but their psychometric properties were relatively poor and their joint application did not improve the outcome. Conclusions We could not create a scale that predicts the 5-HTTLPR genotype with sufficient sensitivity and specificity therefore we could not substitute a psychometric scale for laboratory genetic testing in .