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báo cáo khoa học: "The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field | Journal of Nanobiotechnology BioMed Central Research Open Access The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field Fadee G Mondalek 1 Yuan Yuan Zhang2 Bradley Kropp2 Richard D Kopke3 Xianxi Ge4 Ronald L Jackson4 and Kenneth J Dormer5 Address Department of Chemical Biological and Materials Engineering University of Oklahoma Norman OK USA 2Department of Urology University of Oklahoma Health Sciences Center Oklahoma City OK USA 3Hough Ear Institute Oklahoma City OK USA 4Naval Medical Center San Diego CA USA and 5Department of Physiology University of Oklahoma Health Sciences Center Oklahoma City OK USA Email Fadee G Mondalek - fadee@ou.edu Yuan Yuan Zhang - Yuanyuan-Zhang@ouhsc.edu Bradley Kropp - brad-kropp@ouhsc.edu Richard D Kopke - rickkopke@swbell.net Xianxi Ge -xge@nmcsd.med.navy.mil Ronald L Jackson - rjackson@nmcsd.med.navy.mil Kenneth J Dormer - Kenneth-Dormer@ouhsc.edu Corresponding author Published 07 April 2006 Received 16 November 2005 . J. Z I z-r-rz z Accepted 07 April 2006 Journal of Nanobiotechnology2006 4 4 doi 10.1186 1477-3155-4-4 This article is available from http www.jnanobiotechnology.cOm content 4 1 4 2006Mondalek et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Sensorineural hearing loss a subset of all clinical hearing loss may be correctable through the use of gene therapy. We are testing a delivery system of therapeutics through a 3 cell-layer round window membrane model RWM model that may provide an entry of drugs or genes to the inner ear. We designed an in vitro RWM model similar to the RWM will be referred to throughout the paper as RWM model to determine the feasibility of using superparamagnetic iron oxide Fe3O4 .