tailieunhanh - Báo cáo y học: "Nitric oxide, leukocytes and microvascular permeability: causality or bystanders"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Nitric oxide, leukocytes and microvascular permeability: causality or bystanders? | Available online http content 12 1 104 Commentary Nitric oxide leukocytes and microvascular permeability causality or bystanders Balazs Hauser1 2 Martin Matejovic3 and Peter Radermacher1 1Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum Parkstrasse 11 89073 Ulm Germany 2Aneszteziológiai és Intenziv Terápiás Klinika Semmelweis Egyetem H-1125 Kietvolgyi Budapest Hungary 31. Interni klinika Karlova univerzita Praha Lekarska fakulta a Fakultni nemocnice Allej Svobody 80 30460 Plzen Czech Republic Corresponding author Peter Radermacher Published 16 January 2008 This article is online at http content 12 1 104 2008 BioMed Central Ltd Critical Care 2008 12 104 doi cc6214 See related research by Hollenberg et al. http content 11 6 R125 Abstract Increased microvascular permeability resulting in tissue edema is a hallmark of sepsis-related microcirculatory failure and leukocyteendothelium interaction is thought to assume major importance in this context. However the role of nitric oxide NO in the interplay of inflammation leukocyte-endothelium interaction and increased microcirculatory permeability is still a matter of debate. Hollenberg et al. now report in the previous issue of Critical Care that neither genetic deletion nor pharmacologic blockade of the inducible isoform of the NO synthase iNOS affected the sepsis-related aggravation of leukocyte rolling and adhesion whereas iNOS inhibition attenuated microvascular permeability. The authors conclude that excess NO resulting from iNOS activation is important in modulating vascular permeability during sepsis but that this effect is independent of its action on leukocytes. Increased microvascular permeability resulting in tissue edema is a hallmark of sepsis-related mieroeireulatory failure and in this context leukocytes are thought to assume major importance. However the role of nitric oxide NO in the interplay

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.