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Báo cáo y học: "B cells in autoimmunity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: B cells in autoimmunity. | Available online http arthritis-research.eom content 11 5 247 Review B cells in autoimmunity Thomas Dorner1 Annett M Jacobi1 and Peter E Lipsky2 1 Charite Center 12 and 14 Charite University Hospital and DRFZ Berlin Chariteplatz 01 10098 Berlin Germany 2National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda MD 20892-1560 USA Corresponding author Thomas Dorner thomas.doerner@charite.de Published 14 October 2009 This article is online at http arthritis-research.com content 11 5 247 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 247 doi 10.1186 ar2780 Abstract B-cell development is tightly regulated including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasma-blasts plasma cells in immune regulation under normal and autoimmune conditions with particular emphasis on systemic lupus erythematosus. Based on preclinical and clinical data B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential. Introduction One of the major roles of cells of the B-cell lineage is to generate antibody-secreting plasmablasts and plasma cells and also memory B cells with an enhanced capability to respond to the specific initiating antigen. These effector functions of the B lineage are well recognized and their roles in autoimmune diseases are accepted. Knowledge about the immunoregulatory role of B cells has also been substantially expanded within the last decade and their functions have been reconsidered. Historically B cells have not been thought to play a major regulatory function in the development of autoimmunity and autoimmune diseases although the identification of autoantibodies produced by autoreactive .