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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus. | Available online http arthritis-research.eom content 10 5 R114 Research article Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus Seetha U Monrad Kristine Rea Seth Thacker and Mariana J Kaplan Division of Rheumatology Department of Internal Medicine University of Michigan Medical School 1150 West Medical Center Drive 5520 MSRBI Ann Arbor MI 48109 USA Corresponding author Mariana J Kaplan makaplan@umich.edu Received 6 Aug 2008 Revisions requested 16 Sep 2008 Revisions received 18 Sep 2008 Accepted 23 Sep 2008 Published 23 Sep 2008 Arthritis Research Therapy 2008 10 R114 doi 10.1186 ar2517 This article is online at http arthritis-research.com content 10 5 R114 2008 Monrad et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction There is a growing body of evidence implicating aberrant dendritic cell function as a crucial component in the immunopathogenesis of systemic lupus erythematosus. The purpose of the present study was to characterize the phagocytic capacity and expression of receptors involved in pathogen recognition and self-nonself discrimination on myeloid dendritic cells from patients with lupus. Methods Unstimulated or stimulated monocyte-derived dendritic cells were obtained from lupus patients and healthy control individuals and expression of C-type lectin receptors mannose receptor and dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin complement-receptor 3 and Fcy receptors was determined by flow cytometry. Dextran uptake by lupus and control dendritic cells was also assessed by flow cytometry. Serum IFNy was quantified by ELISA and uptake of microbial products was .