tailieunhanh - Báo cáo y học: " Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab. | Available online http content 11 3 R100 Research article Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab Christophe Richez1 2 Thierry Schaeverbeke1 Chantal Dumoulin1 Joel Dehais1 Jean- Franpois Moreau2 3 and Patrick Blanco2 3 4 1Département de Rhumatologie CHU Bordeaux place Amélie Raba-Léon 33076 Bordeaux France 2UMR-CNRS 5164 Université Bordeaux 2 146 rue Léo Saignat 33076 Bordeaux France 3Département de Virologie et d lmmunologie biologique CHU Bordeaux place Amélie Raba-Léon 33076 Bordeaux France 4Service de Médecine Interne CHU Bordeaux 1 Avenue de Magellan 33600 Pessac France Corresponding author Christophe Richez Patrick Blanco Received 15 Oct 2008 Revisions requested 19 Dec 2008 Revisions received 11 May 2009 Accepted 29 Jun 2009 Published 29 Jun 2009 Arthritis Research Therapy 2009 11 R100 doi 86 ar2746 This article is online at http content 11 3 R100 2009 Richez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective of our study was to identify the significance of the subtypes of dendritic cell DC specifically myeloid DCs mDCs and plasmacytoid DCs pDCs in rheumatoid arthritis RA pathogenesis through their longitudinal follow-up in patients receiving infliximab. Methods Circulating mDC and pDC levels were evaluated by flow cytometry in RA patients n 61 and healthy volunteers n 30 . In RA patients these levels were measured before and during infliximab therapy. Their counts were correlated to RA disease activity markers and .