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báo cáo khoa học: "Journal of Hematology & Oncology BioMed Central Short report Open Access Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia | BioMed Central Journal of Hematology Oncology Open Access Short report Detection of NPMI exon 12 mutations and FLT3 - internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia Angela YC Tan1 David A Westerman1 2 3 Dennis A Carney2 John F Seymour2 Surender Juneja4 and Alexander Dobrovic 1 3 Address Department of Pathology Peter MacCallum Cancer Centre Melbourne Australia 2Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Melbourne Australia 3Department of Pathology University of Melbourne Parkville Australia and 4Royal Melbourne Hospital Parkville Australia Email Angela YC Tan - angela.tan@petermac.org David A Westerman - david.westerman@petermac.org Dennis A Carney - dennis.carney@petermac.org John F Seymour - john.seymour@petermac.org Surender Juneja - surender.juneja@mh.org.au Alexander Dobrovic - alexander.dobrovic@petermac.org Corresponding author Published 29 July 2008 Received 20 May 2008 Journal of Hematology Oncology 2008 1 10 doi 10.1186 1756-8722-1-10 Accepted 29 July 2008 This article is available from http www.jhoonline.Org content 1 1 10 2008 Tan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Molecular characterisation of normal karyotype acute myeloid leukemia NK-AML allows prognostic stratification and potentially can alter treatment choices and pathways. Approximately 45-60 of patients with NK-AML carry NPMI gene mutations and are associated with a favourable clinical outcome when FLT3-internal tandem duplications ITD are absent. High resolution melting HRM is a novel screening method that enables rapid .