tailieunhanh - Báo cáo y học: "Evidence-Based Medicine Journal Club EBM Journal Club Section Editor: Eric B. Milbrandt, MD, MPH"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Evidence-Based Medicine Journal Club EBM Journal Club Section Editor: Eric B. Milbrandt, MD, MPH. | Available online at http content 8 6 E2 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique The routine use of albumin for fluid resuscitation of critically ill patients is not warranted Shakeel Amanullah1 and Ramesh Venkataraman2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 1 November 2004 This article is online at http content 8 6 E2 2004 BioMed Central Ltd Critical Care 2004 8 E2 DOI cc3006 Expanded Abstract Citation Finfer S Bellomo R Boyce N French J Myburgh J Norton R SAFE Study Investigators A comparison of albumin and saline for fluid resuscitation in the intensive care unit. NEJM 2004 350 Hypothesis When 4 albumin is compared with sodium chloride normal saline for intravascular-fluid resuscitation in patients in the intensive care unit ICU there is no difference in the 28-day rate of death from any cause. Methods Design Multicenter double blind randomized controlled trial Setting Closed multidisciplinary ICUs of 16 academic tertiary hospitals in Australia and New Zealand between November 2001 and June 2003 Patients 6997 ICU patients 18 years of age who were judged by their treating physician to require fluid resuscitation to maintain or increase intravascular volume with this decision supported by the fulfillment of at least one objective criterion. Patients admitted to the ICU after cardiac surgery after liver transplantation or for the treatment of burns were excluded. Intervention Patients were randomly assigned to receive either 4 albumin or normal saline with randomization stratified according to institution and whether there was a diagnosis of trauma on