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Báo cáo y học: "Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. | Available online http arthritis-research.eom content 10 4 R98 Research article Identification of intra-group inter-individual and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane René Huber1 2 Christian Hummert3 Ulrike Gausmann4 Dirk Pohlers1 Dirk Koczan5 Reinhard Guthke3 and Raimund W Kinne1 Open Access Experimental Rheumatology Unit Department of Orthopedics University Hospital Jena Waldkrankenhaus Rudolf Elle Klosterlausnitzer Str. 81 07607 Eisenberg Germany institute for Clinical Chemistry Hannover Medical School Carl-Neuberg-Str. 1 30625 Hannover Germany 3Systems Biology Bioinformatics Group Department of Molecular and Applied Microbiology Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoll Institute Beutenbergstr. 11a 07745 Jena Germany 4Genome Analysis Leibniz Institute for Age Research - Fritz Lipmann Institute Beutenbergstr. 11 07745 Jena Germany 5Proteome Center Rostock University of Rostock Schillingallee 69 18055 Rostock Germany Corresponding author Raimund W Kinne Raimund.W.Kinne@med.uni-jena.de Received 25 Oct 2007 Revisions requested 5 Dec 2007 Revisions received 16 Jul 2008 Accepted 22 Aug 2008 Published 22 Aug 2008 Arthritis Research Therapy 2008 10 R98 doi 10.1186 ar2485 This article is online at http arthritis-research.com content 10 4 R98 2008 Huber et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Rheumatoid arthritis RA is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory pro-destructive genes and other activating genes for example proto-oncogenes in the synovial membrane SM . The gene expression in disease is often characterized by significant

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