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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65. | Available online http arthritis-research.eom content 9 4 R70 Research article Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65 Li Tong1 and Kamal D Moudgil1 2 Department of Microbiology and Immunology Department of Medicine University of Maryland School of Medicine Baltimore MD 21 201 USA 2Division of Rheumatology Department of Medicine University of Maryland School of Medicine Baltimore MD 21 201 USA Corresponding author Kamal D Moudgil kmoud001@umaryland.edu Received 4 Mar 2007 Revisions requested 1 May 2007 Revisions received 15 Jun 2007 Accepted 23 Jul 2007 Published 23 Jul 2007 Arthritis Research Therapy 2007 9 R70 doi 10.1186 ar2268 This article is online at http arthritis-research.com content 9 4 R70 2007 Tong and Moudgil. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However the mechanisms of action of these agents are not fully defined. Using the rat adjuvant arthritis AA model of human rheumatoid arthritis we determined whether the ethanol extract of Celastrus aculeatus Merr. Celastrus a Chinese herb can down-modulate the severity of AA and also examined the Celastrus-induced changes in immune responses to the disease-related antigen mycobacterial heat-shock protein 65 Bhsp65 . AA was induced in the Lewis LEW RT.11 rat by immunization subcutaneously with heat-killed M. tuberculosis H37Ra Mtb . Celastrus was fed to LEW rats by gavage daily beginning either before Mtb challenge preventive regimen or after the onset of AA therapeutic regimen . An additional group of rats was given .