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Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Review Cells of the synovium in rheumatoid arthritis. | Available online http arthritis-research.eom content 9 6 224 Review Cells of the synovium in rheumatoid arthritis Macrophages Raimund W Kinne1 Bruno Stuhlmuller2 and Gerd-R Burmester2 1 Experimental Rheumatology Unit Department of Orthopedics University Clinic Jena Klosterlausnitzer Str. 81 D-07607 Eisenberg Germany 2Department of Rheumatology and Clinical Immunology Charité University Hospital Humboldt University of Berlin Tucholskystr. 2 D-10117 Berlin Germany Corresponding author Raimund W Kinne raimund.w.kinne@med.uni-jena.de Published 21 December 2007 This article is online at http arthritis-research.com content 9 6 224 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 224 doi 10.1186 ar2333 Abstract The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate means to silence the pathogenetic process efforts in understanding how activated macrophages influence disease have led to optimization strategies to selectively target macrophages by agents tailored to specific features of macrophage activation. This approach has two advantages a striking the cell population that mediates amplifies most of the irreversible tissue destruction and b sparing other cells that have no or only marginal effects on joint damage. Introduction Macrophages MỘ are of central importance in rheumatoid arthritis RA due to their prominent numbers in the inflamed synovial membrane and at the cartilage-pannus junction their clear activation status 1 2 see Table 1 for overview and their response to successful anti-rheumatic treatment 3 . Although MỘ probably do not occupy a causal pathogenetic position in RA except for their potential antigen-presenting capacity they possess broad pro-inflammatory destructive and remodelling potential and contribute considerably to inflammation .