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Báo cáo y học: "Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis. | Available online http arthritis-research.eom content 10 3 R51 Research article Anti-cyclic citrullinated peptide antibodies in primary Sjogren syndrome may be associated with non-erosive synovitis Fabiola Atzeni1 Piercarlo Sarzi-Puttini1 Nicola Lama2 Eleonora Bonacci3 Francesca Bobbio- Pallavicini3 Carlomaurizio Montecucco3 and Roberto Caporali3 Rheumatology Unit L. Sacco Hospital University of Milan Via G.B. Grassi 74 20127 Milan Italy 2Department of Medicine and Public Health Second University of Naples Via L Armanni 75 80139 Naples Italy 3University of Pavia IRCCS Policlinico S. Matteo Piazzale Golgi 12 27100 Pavia Italy Corresponding author Piercarlo Sarzi-Puttini sarzi@tiscali.it Received 15 Nov 2007 Revisions requested 18 Dec 2007 Revisions received 6 Apr 2008 Accepted 7 May 2008 Published 7 May 2008 Arthritis Research Therapy 2008 10 R51 doi 10.1186 ar2420 This article is online at http arthritis-research.com content 10 3 R51 2008 Atzeni et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The purpose of this study was to investigate the prevalence of eyelie citrullinated peptide antibodies anti-CCP in patients with primary Sjogren syndrome pSS and its correlation with clinical and laboratory data. Methods We analysed the clinical and serological data of 155 consecutive patients with pSS. Among these 14 were excluded due to fulfillment of American College of Rheumatology criteria for rheumatoid arthritis RA . So 141 patients 27 males and 114 females mean age 48 years range 39 to 60 were clinically assessed for the presence of synovitis objective swelling of one or more joints and extra-glandular involvement. The anti-CCP antibodies were tested using a commercially available .