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Báo cáo y học: "Reshaping Cinderella’s slipper: the shared epitope hypothesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reshaping Cinderella’s slipper: the shared epitope hypothesis. | Available online http arthritis-research.eom content 8 3 109 Commentary Reshaping Cinderella s slipper the shared epitope hypothesis Robert Winchester Departments of Medicine Pediatrics and Pathology Columbia University New York NY 10032 USA Corresponding author Robert Winchester rjw8@columbia.edu Published 22 May 2006 Arthritis Research Therapy 2006 8 109 doi 10.1186 ar1970 This article is online at http arthritis-research.com content 8 3 109 2006 BioMed Central Ltd See related research article by Michou et al. http arthritis-research.com content 8 3 R79 Abstract This issue of Arthritis Research and Therapy contains a succinct and elegant paper by Michou and colleagues that advances our understanding of the genetic basis of rheumatoid arthritis RA by reclassifying the contribution of RA susceptibility alleles according to their structure. This line of research is potentially important in our conceptualization of the mechanism of disease in RA in predicting disease course and severity and as a model for further studies on this topic. The author s approach to reassessing the molecular structure of the shared epitope redirects attention to using the binding properties of the major histocompatibility complex molecules associated with susceptibility to search for the peptides driving the autoimmune process underlying rheumatoid arthritis This issue of Arthritis Research and Therapy contains a succinct and elegant paper by Michou and colleagues 1 that advances our understanding of the genetic basis of RA by reclassifying the contribution of RA susceptibility alleles according to their structure. This line of research is potentially important in our conceptualization of the mechanism of disease in RA in predicting disease course and severity and as a model for further studies on this topic. More than 10 different HLA-DRB alleles predispose to the development of rheumatoid arthritis RA and this number alone distinguishes RA from many other autoimmune diseases. Over two .