Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Proteinases in the joint: clinical relevance of proteinases in joint destruction Yvonne Rengel, Caroline Ospelt and Steffen Gay"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Proteinases in the joint: clinical relevance of proteinases in joint destruction Yvonne Rengel, Caroline Ospelt and Steffen Gay. | Available online http arthritis-research.eom content 9 5 221 Review Proteinases in the joint clinical relevance of proteinases in joint destruction Yvonne Rengel Caroline Ospelt and Steffen Gay Center of Experimental Rheumatology University Hospital Zurich Gloriastrasse CH-8091 Zurich Switzerland Corresponding author Steffen Gay steffengay@usz.ch Published 31 October 2007 This article is online at http arthritis-research.com content 9 5 221 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 221 doi 10.1186 ar2304 Abstract Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis osteoarthritis and spondyloarthritis. Matrix metalloproteinases MMPs are sensitive markers of disease severity and response to treatment and therefore they have potential in the assessment of rheumatic diseases. Despite disappointing early results with synthetic inhibitors of MMPs there is still much scope for developing effective and safe MMPs inhibitors and consequently to deliver new options to inhibit joint destruction. Introduction Proteases are responsible for enzymatic cleavage of peptide bonds 1 2 which is a basic requirement for completion of diverse biological processes. Examples of contributions made by proteases can be found in digestion blood coagulation and fibrinolysis. They are also involved in the processing of precursors related to the synthesis of collagen immune functions development and apoptosis 3 . The proteolytic activity of proteases must be rigorously controlled to avoid inappropriate degradation of proteins. Imbalance in regulation of proteolytic activity can be found in a wide range of diseases including cancer rheumatoid arthritis RA and osteoarthritis OA 4 . Of particular importance is that proteases have been found to play diverse and strategic roles in cartilage and bone remodelling which in .