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Báo cáo y học: "Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis. | Available online http arthritis-research.eom content 8 6 R162 Research article Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis Andrea Becker-Merok1 Manar Kalaaji2 Kaia Haugbro2 Cathrin Nikolaisen1 Kirsten Nilsen1 Ole Petter Rekvig2 3 and Johannes C Nossent1 3 Department of Rheumatology Institute of Clinical Medicine University of Tromso Breivika N-9037 Tromso Norway department of Biochemistry Institute of Medical Biology University of Tromso Breivika N-9037 Tromso Norway department of Rheumatology University Hospital of North Norway Tromso Breivika N-9038 Tromso Norway Corresponding author Andrea Becker-Merok andrea.becker-merok@unn.no Received 19 Jun 2006 Revisions requested 27 Jul 2006 Revisions received 25 Sep 2006 Accepted 24 Oct 2006 Published 24 Oct 2006 Arthritis Research Therapy 2006 8 R162 doi 10.1186 ar2070 This article is online at http arthritis-research.com content 8 6 R162 2006 Becker-Merok et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract This study investigated the overall clinical impact of anti-a-actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody ANA -positive individuals. The relation of anti-a-actinin antibodies with lupus nephritis and anti-double-stranded DNA anti-dsDNA antibodies represented a particular focus for the study. Using a cross-sectional design the presence of antibodies to a-actinin was studied in selected groups classified according to the relevant American College of Rheumatology classification criteria for systemic lupus erythematosus SLE n 99 rheumatoid arthritis RA n 68 Wegener s granulomatosis WG n 85 and fibromyalgia FM n 29 and in a random .