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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases. | Wybranski et al. Radiation Oncology 2011 6 43 http www.ro-journal.eom content 6 1 43 RADIATION ONCOLOGY RESEARCH Open Access Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases 11 111 2 Christian Wybranski Martin Zeile David Lowenthal Frank Fischbach Maciej Pech Friedrich-Wilhelm Rohl Gunther Gademann3 Jens Ricke1 and Oliver Dudeck1 Abstract Background To assess the value of diffusion weighted imaging DWI as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction 192Ir-high-dose-rate brachytherapy HDR-BT . Methods Thirty patients with a total of 43 metastases underwent CT- or MRI-guided HDR-BT. In 13 of these patients a total of 15 additional lesions were identified which were not treated at the initial session and served for comparison. Magnetic resonance imaging MRI including breathhold echoplanar DWI sequences was performed prior to therapy baseline MRI 2 days after HDR-BT early MRI as well as after 3 months follow-up MRI . Tumor volume TV and intratumoral apparent diffusion coefficient ADC were measured independently by two radiologists. Statistical analysis was performed using univariate comparison ANOVA and paired t test as well as Pearson s correlation. Results At early MRI no changes of TV and ADC were found for non-treated colorectal liver metastases. In contrast mean TV of liver lesions treated with HDR-BT increased by 8.8 p 0.054 while mean tumor ADC decreased significantly by 11.4 p 0.001 . At follow-up MRI mean TV of non-treated metastases increased by 50.8 p 0.027 without significant change of mean ADC values. In contrast mean TV of treated lesions decreased by 47.0 p 0.026 while the mean ADC increased inversely by 28.6 compared to baseline values p 0.001 Pearson s correlation coefficient of r -0.257 p 0.001 . Conclusions DWI is a promising imaging biomarker for early prediction .