tailieunhanh - Báo cáo khoa học: "Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. | Available online http content 10 5 R145 Research Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery a systematic review of the literature Christoph Sponholz Yasser Sakr Konrad Reinhart and Frank Brunkhorst Department of Anesthesiology and Intensive Care Friedrich-Schiller-University Erlanger Allee 103 07743 Jena Germany Corresponding author Konrad Reinhart Received 12 Jul 2006 Revisions requested 9 Aug 2006 Revisions received 24 Sep 2006 Accepted 13 Oct 2006 Published 13 Oct 2006 Critical Care 2006 10 R145 doi cc5067 This article is online at http content 10 5 R145 2006 Sponholz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Systemic inflammatory response syndrome is common after surgery and it can be difficult to discriminate between infection and inflammation. We performed a review of the literature with the aims of describing the evolution of serum procalcitonin PCT levels after uncomplicated cardiac surgery characterising the role of PCT as a tool in discriminating infection identifying the relation between PCT organ failure and severity of sepsis syndromes and assessing the possible role of PCT in detection of postoperative complications and mortality. Methods We performed a search on MEDLINE using the keyword procalcitonin crossed with cardiac surgery heart postoperative and transplantation. Our search was limited to human studies published between January 1990 and June 2006. Results Uncomplicated cardiac surgery induces a postoperative increase in serum PCT levels. Peak PCT levels are reached within 24 hours postoperatively and return to normal levels within the first week.