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Báo cáo y học: "Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. | Available online http arthritis-research.eom content 7 6 R1281 Research article Open label phase II trial of single ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement Patricia Woo1 Nicholas Wilkinson1 Anne-Marie Prieur2 Taunton Southwood3 Valentina Leone3 Polly Livermore1 Helena Wythe1 David Thomson4 and Tadamitsu Kishimoto5 1Great Ormond Street Hospital NHS Trust London UK 2Hopital Necker Enfants Malades Paris France 3University of Birmingham and Birmingham Children s Hospital NHS Trust Birmingham UK 4Chugai Pharma Europe Ltd London UK 5Laboratory of Immune Regulation Graduate School of Frontier Biosciences Osaka University Osaka Japan Corresponding author Patricia Woo patricia.woo@ucl.ac.uk Received 13 May 2005 Revisions requested 15 Jun 2005 Revisions received 3 Aug 2005 Accepted 24 Aug 2005 Published 15 Sep 2005 Arthritis Research Therapy 2005 7 R1281-R1 288 DOI 10.1186 ar1826 This article is online at http arthritis-research.com content 7 6 R1281 2005 Woo et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Eighteen Caucasian white Middle East and Asian children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis sJIA were enrolled in this open label single dose trial. All patients had evidence of continued symptoms and disease activity for at least three months while receiving 0.2 mg kg day of prednisolone or its equivalent prior to recruitment. Twelve patients also received methotrexate 20 mg m2 week . The patients were divided into three groups receiving 2