tailieunhanh - Báo cáo y học: " Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy-a single centre, open-label study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy-a single centre, open-label study. | Pontifex et al. Arthritis Research Therapy 2011 13 R7 http content 13 1 R7 RESEARCH ARTICLE Open Access Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy-a single centre open-label study 1 2 1 2 12 Eliza K Pontifex Danielle M Gerlag Martina Gogarty Marjolein Vinkenoog Adrian Gibbs Ilse Burgman 112 3 1 1 Ursula Fearon Barry Bresnihan Paul Peter Tak Robin G Gibney Douglas J Veale Oliver FitzGerald Abstract Introduction With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials OMERACT group which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis PsA we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints ADAS28 or magnetic resonance imaging synovitis scores AMRI in patients with PsA treated with a biologic agent. Methods Twenty-five consecutive patients with PsA underwent arthroscopic synovial biopsies and MRI scans of an inflamed knee joint at baseline and 12 weeks after starting treatment with either anakinra first 10 patients or etanercept subsequent 15 patients in two sequential studies of identical design. DAS28 scores were measured at both time points. Immunohistochemical staining for CD3 CD68 and Factor VIII FVIII was performed on synovial samples and scored by digital image analysis DIA . MRI scans performed at baseline and at 12 weeks were scored for synovitis semi-quantitatively. The ADAS28 of the European League Against Rheumatism good response .