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Báo cáo y học: "Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation. | Available online http arthritis-research.eom content 7 4 R837 Research article Osteoporosis in experimental postmenopausal polyarthritis the relative contributions of estrogen deficiency and inflammation Caroline Jochems1 Ulrika Islander1 Malin Erlandsson1 Margareta Verdrengh1 Claes Ohlsson2 and Hans Carlsten1 Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy Goteborg Sweden 2Center for Bone Research at the Sahlgrenska Academy CBS Goteborg Sweden Corresponding author Caroline Jochems caroline.jochems@rheuma.gu.se Received 18 Feb 2005 Revisions requested 18 Mar 2005 Revisions received 1 Apr 2005 Accepted 1 2 Apr 2005 Published 27 Apr 2005 Arthritis Research Therapy 2005 7 R837-R843 DOI 10.11 86 ar1 753 This article is online at http arthritis-research.com content 7 4 R837 2005 Jochems et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Generalized osteoporosis in postmenopausal rheumatoid arthritis RA is caused both by estrogen deficiency and by the inflammatory disease. The relative importance of each of these factors is unknown. The aim of this study was to establish a murine model of osteoporosis in postmenopausal RA and to evaluate the relative importance and mechanisms of menopause and arthritis-related osteoporosis. To mimic postmenopausal RA DBA 1 mice were ovariectomized followed by the induction of type II collagen-induced arthritis. After the mice had been killed paws were collected for histology one femur for bone mineral density BMD and sera for analyses of markers of bone resorption RatLaps type I collagen cross-links bone formation osteocalcin and cartilage destruction cartilage oligomeric matrix protein and for the evaluation of antigen-specific and innate