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Báo cáo y học: "CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. | Available online http arthritis-research.eom content 8 2 R38 Research article Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus Stefan CA Steens1 Gerlof PTh Bosma1 Gerda M Steup-Beekman2 Saskia le Cessie3 Tom WJ Huizinga2 and Mark A van Buchem1 1Department of Radiology Leiden University Medical Center Leiden The Netherlands 2Department of Rheumatology Leiden University Medical Center Leiden The Netherlands 3Department of Medical Statistics and Bio-informatics Leiden University Medical Center Leiden The Netherlands Corresponding author Stefan CA Steens s.c.a.steens@lumc.nl Received 1 Aug 2005 Revisions requested 31 Aug 2005 Revisions received 18 Dec 2005 Accepted 20 Dec 2005 Published 16 Jan 2006 Arthritis Research Therapy 2006 8 R38 doi 10.1186 ar1 892 This article is online at http arthritis-research.com content 8 2 R38 2006 Steens et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The pathogenetic role of anticardiolipin antibodies aCLs in patients with neuropsychiatric systemic lupus erythematosus NPSLE without cerebral infarcts remains elusive. Magnetization transfer imaging MTI has proved to be a sensitive tool for detecting diffuse microscopic brain damage in NPSLE patients. In this study we examined the correlation between grey and white matter magnetization transfer ratio MTR parameters and the presence of IgM and IgG aCLs and lupus anticoagulant in 18 patients with systemic lupus erythematosus and a history of NPSLE but without cerebral infarcts on conventional magnetic resonance imaging. Lower grey matter mean MTR P 0.05 white matter mean MTR P 0.05 white matter peak location P 0.05 and grey