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Báo cáo y học: "Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]. | Available online http arthritis-research.eom content 6 5 R457 Research article Hormone replacement therapy calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis a randomized controlled trial ISRCTN46523456 Helena Forsblad d Elia1 Stephan Christgau2 Lars-Ảke Mattsson3 Tore Saxne4 Claes Ohlsson5 Elisabeth Nordborg1 and Hans Carlsten1 1 Department of Rheumatology and Inflammation Research The Sahlgrenska Academy at Goteborg University Goteborg Sweden 2Nordic Bioscience A S Osteopark Herlev Denmark 3Department of Obstetrics and Gynecology The Sahlgrenska Academy at Goteborg University Goteborg Sweden 4Department of Rheumatology Lund University Hospital Lund Sweden 5Department of Internal Medicine The Sahlgrenska Academy at Goteborg University Goteborg Sweden Corresponding author Helena Forsblad d Elia helena.forsblad@rheuma.gu.se Received 8 Mar 2004 Revisions requested 16 Apr 2004 Revisions received 6 Jun 2004 Accepted 21 Jun 2004 Published 6 Aug 2004 Arthritis Res Ther 2004 6 R457-R468 DOI 10.1186 ar1215 2004 Forsblad d Elia et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract This study aimed to evaluate the effects of hormone replacement therapy HRT known to prevent osteoporosis and fractures on markers of bone and cartilage metabolism. Furthermore we assessed whether changes in these markers corresponded to alterations in bone mineral density and radiographic joint destructions in postmenopausal women with rheumatoid arthritis. Eighty-eight women were randomized to receive HRT calcium and vitamin D3 or calcium and vitamin D3 alone for 2 years. Bone turnover was studied by analyzing serum levels of C-terminal telopeptide fragments of type I collagen CTX-I C-terminal telopeptide of type I