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Báo cáo y học: "Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats. | Int. J. Med. Sci. 2010 7 232 International Journal of Medical Sciences 2010 7 4 232-239 Ivyspring International Publisher. All rights reserved Research Paper Influence of Cyclodextrin Complexation with NSAIDs on NSAID Cold Stress-Induced Gastric Ulceration in Rats Ibrahim A. Alsarra1 2 H Mahrous O. Ahmed1 Fars K. Alanazi1 3 Kamal Eldin Hussein ElTahir4 Abdulmalik M. Alsheikh5 and Steven H. Neau6 1. Department of Pharmaceutics College of Pharmacy King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia 2. Center of Excellence in Biotechnology Research King Saud University P.O. Box 2460 Riyadh 11451 Saudi Arabia 3. Kayyali Chair for Pharmaceutical Industry College of Pharmacy King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia 4. Department of Pharmacology College of Pharmacy King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia 5. Department of Pathology Faculty of Medicine King Saud University P.O. Box 2925 Riyadh 11461 Saudi Arabia 6. Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences in Philadelphia 600 South 43rd Street Philadelphia PA 19104 USA H Corresponding author Dr. Ibrahim A. Alsarra Phone 966 -1-4677504 Fax 966 -1-4676363 E-mail ialsar-ra@ksu.edu.sa Received 2010.04.15 Accepted 2010.06.30 Published 2010.07.05 Abstract The aim of this work was to study the ability of P-cyclodextrin P-CD or hydroxypropyl P-cyclodextrin HP-P-CD to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug indomethacin or piroxicam in rats exposed to restraint and hypothermic stress at 4 C. Using oral gavage rats fasted for 72 h were administered the equivalent of a 100 mg kg dose of the assigned drug alone or with the designated cyclodextrin CD . The rats were placed in suitable rodent restrainers and then placed inside a ventilated refrigerator maintained at a temperature of 4 C. Six hours later each animal was removed anaesthetized with ether and the abdomen opened. Each stomach .