tailieunhanh - Báo cáo y học: "Transporter Molecules influence the Gene Expression in HeLa Cells"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Transporter Molecules influence the Gene Expression in HeLa Cells. | Int. J. Med. Sci. 2009 6 18 Research Paper International Journal of Medical Sciences 2009 6 1 18-27 Ivyspring International Publisher. All rights reserved Transporter Molecules influence the Gene Expression in HeLa Cells Waldemar Waldeck1 Ruediger Pipkorn2 Bernhard Korn3 Gabriele Mueller1 Matthias Schick3 Katalin Tóth1 Manfred Wiessler4 Bernd Didinger5 Klaus Braun4 H 1. German Cancer Research Center Division of Biophysics of Macromolecules INF 580 D-69120 Heidelberg Germany 2. German Cancer Research Center Central Peptide Synthesis Unit INF 580 D-69120 Heidelberg Germany 3. German Cancer Research Center Genomics and Proteomics Core Facilities INF 580 D-69120 Heidelberg Germany 4. German Cancer Research Center Dept. of Medical Physics in Radiology INF 280 D-69120 Heidelberg Germany 5. University of Heidelberg Dept. of Radiation Oncology INF 400 D-69120 Heidelberg Germany H Correspondence to Klaus Braun . German Cancer Research Center DKFZ Dept. Medical Physics in Radiology Im Neuenheimer Feld 280 D-69120 Heidelberg Germany. Phone 49 6221-42 2495 Fax 49 6221-42 3375 e-mail . de Received Accepted Published Abstract Progresses in biology and pharmacology led to highly specific bioactive substances but their poor bioavailability at the site of action is a result of their physico-chemical properties. Various design approaches for transport carrier molecules facilitating the cellular entry of bioactive substances could help to reach their molecular target in cells and tissues. The transfer efficacy and the subsequent pharmacological effects of the cargo molecules are well investigated but the investigations of effects of the carrier molecules themselves on the target cells or tissues remain necessary. A special attention should be paid to the differential gene expression particularly in the interpretation of the data achieved by highly specific active pharmaceutical products. After application of transmembrane transport .