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Báo cáo y học: "Polymorphisms in melatonin synthesis pathways: possible influences on depression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Polymorphisms in melatonin synthesis pathways: possible influences on depression. | Kripke et al. Journal of Circadian Rhythms 2011 9 8 http www.jcircadianrhythms.eom content 9 1 8 JOURNAL OF CIRCADIAN RHYTHMS RESEARCH Open Access Polymorphisms in melatonin synthesis pathways possible influences on depression Daniel F Kripke1 2 Caroline M Nievergelt1 Greg J Tranah3 Sarah S Murray4 Michael J McCarthy1 5 Katharine M Rex1 Neeta Parimi3 and John R Kelsoe1 5 Abstract Background It has been reported that rs4446909 a single nucleotide polymorphism SNP in the promoter of acetylserotonin methyltransferase ASMT influences the expression of the ASMT enzyme. The common G allele is associated with lower ASMT activity and therefore diminishes conversion of N-acetylserotonin to melatonin. The G allele was associated with recurrent depressive disorder in a Polish group. ASMT might also affect bipolar relapse given evidence that N-acetylserotonin might stimulate TRKB receptors and TRKB may influence mood relapse in bipolar disorder. Additionally arylalkylamine N-acetyltransferase AANAT polymorphisms have been reported associated with depression perhaps through their influence upon N-acetylserotonin or melatonin synthesis. Results To replicate and further explore these ideas rs4446909 was genotyped in four research groups as part of a panel of 610 SNPs surveyed by an Illumina Golden Gate assay. In 768 cases with delayed sleep phase disorder or matched controls rs4446909 was indeed associated with the depressive symptoms on a self-report scale P 0.01 R2 0.007 . However there was no significant association of rs4446909 with self-reported depression in a sleep clinic patient group or with two groups of elderly men and women from multicenter studies nor was the response to lithium treatment associated with rs4446909 in bipolar patients. No associations of two AANAT SNPs with depression were found. Conclusions The evidence did not support a strong influence of rs4446909 upon mood but the partial replication may be consistent with a modest effect. It is possible that .