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Báo cáo y học: " Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India. | Neogi et al. AIDS Research and Therapy 2010 7 24 http www.aidsrestherapy.eom content 7 1 24 AIDS RESEARCH AND THERAPY SHORT REPORT Open Access Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences Therapeutic implications for India Ujjwal Neogi1 4 Sreenivasa B Prarthana2 George D Souza2 Ayesha DeCosta2 4 Vijesh S Kuttiatt3 Udaykumar Ranga5 Anita Shet3 4 Abstract Background Understanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antagonists among Indian HIV-infected populations. The objective of this study was to determine using in silico methods HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences. Results R5-tropism was seen in 96.8 of a total of 1045 HIV-1 subtype C Indian sequences. Co-receptor prediction of 15 primary clinical isolates detected two X4-tropic strains using the C-PSSM matrix. R5-tropic HIV-1 subtype C V3 sequences were conserved to a greater extent than X4-tropic strains. X4-tropic strains were obtained from subjects who had a significantly longer time since HIV diagnosis 96.5 months compared to R5-tropic strains 20.5 months . Conclusions High prevalence of R5 tropism and greater homogeneity of the V3 sequence among HIV-1 subtype C strains in India suggests the potential benefit of CCR5 antagonists as a therapeutic option in India. Background After the discovery of the CD4 molecule as the major cellular receptor for HIV entry 1 2 multiple studies suggested the presence of a secondary cellular receptor for HIV entry into the human CD4 cell 3 4 . These coreceptors particularly the chemokine receptors CCR5 and CXCR4 have been the subject of much research attempting to elucidate viral entry mechanisms disease progression antiretroviral therapy and vaccine development. Based on co-receptor usage viral .