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Báo cáo y học: " Opportunistic illnesses in Brazilian children with AIDS: results from two national cohort studies, 1983-2007"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Opportunistic illnesses in Brazilian children with AIDS: results from two national cohort studies, 1983-2007. | Ramos et al. AIDS Research and Therapy 2011 8 23 http www.aidsrestherapy.eom content 8 1 23 AIDS RESEARCH AND THERAPY RESEARCH Open Access Opportunistic illnesses in Brazilian children with AIDS results from two national cohort studies 1983-2007 Alberto N Ramos Jr1 Luiza H Matida2 Norman Hearst3 and Jorg Heukelbach1 Abstract Background HAART has significantly reduced AIDS-related morbidity in children. However limited evidence is available from developing countries regarding patterns of opportunistic illnesses. We describe these events and their associated factors in children with AIDS in Brazil. Methods This study is based on two representative retrospective multi-center cohorts including a total 1 859 children with AIDS infected via mother-to-child transmission MTCT between 1983-2002. Opportunistic illnesses were described and analyzed over time. The association of demographic clinical and operational data with the occurrence of opportunistic diseases was assessed. Results In total 1 218 65.5 had at least one event of an opportunistic disease. Variables significantly associated with occurrence of these events included region of residence OR 2.68-11.33 as compared to the Northern region age 1 year at diagnosis OR 2.56 95 CI 1.81-3.61 p 0.001 and non-performance of MTCT prevention measures OR 1.58 95 CI 1.21-2.07 p 0.001 . Protective factors included year of HIV diagnosis in the HAART era OR 0.34 95 CI 0.15-0.76 p 0.009 and ART use OR 0.58 95 CI 0.44-0.77 p 0.001 . In both periods bacterial infections represented the most common opportunistic events 58.6 vs. 34.7 p 0.001 followed by Pneumocystis jirovecii pneumonia 21.9 vs. 13.2 p 0.001 and bacterial meningitis sepsis 16.8 vs. 7.4 p 0.001 . Conclusions Despite the significant reduction in recent years opportunistic illnesses are still common in Brazilian children with AIDS in the HAART era especially bacterial diseases. The data reinforce the need for scaling up prevention of MTCT early diagnosis of infection and .