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Báo cáo y học: " Ten years of Genome Biolog"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Ten years of Genome Biology. | Garvey Genome Biology 2010 11 101 http genomebiology.eom 2010 11 1 101 w Genome Biology EDITORIAL L_ Ten years of Genome Biology Clare Garvey Editor Genome Biology Abstract Huge advances in the field of genomics along with the continued rise of open access has made the past ten years an exciting time to be a biologist. Over the past decade we have witnessed a revolution in biology and especially in molecular biology and genetics. No longer are experiments restricted to the study of a particular gene in one of a small number of model organisms. Today a more global approach is being embraced which has not only given rise to the field of systems biology but has also touched all areas of biological and medical research bringing them closer together and blurring the lines that previously defined individual disciplines. And our expectations are now much higher. It no longer satisfies us to know simply that a given transcription factor activates a particular gene. We now want to know about all of the regulatory sites for a gene and what other factors might modulate transcription factor binding and gene activation. Horizons and expectations have broadened but what has driven this shift in attitude It surely has to be the technological advances in the field of genomics over the past decade such as chromatin immunoprecipitation coupled to DNA microarray ChIP-chip or sequencing ChIP-seq nextgeneration sequencing RNA-seq and new techniques in proteomics. Techniques aside the past decade will surely be best remembered as the decade of the genome. Since the White House press release http www.ornl.gov sci techresources Human_Genome project clinton1.shtml in June 2000 in which the completion of the initial sequence of the human genome was announced -followed by publications in 2001 in Nature and Science -many draft genomes from other organisms have been published. The chimpanzee chicken honeybee and Arabidopsis have most recently been followed by the Correspondence .