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Báo cáo y học: "Cancer, oncogenes and signal transduction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Cancer, oncogenes and signal transduction. | Meeting report Cancer oncogenes and signal transduction Edward J McManus and Dario R Alessi Address Medical Research Council Protein Phosphorylation Unit School of Life Sciences University of Dundee Dow Street Dundee DD1 5EH UK. Correspondence Edward J McManus. E-mail e.j.mcmanus@dundee.ac.uk Published 24 June 2004 Genome Biology 2004 5 332 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 7 332 2004 BioMed Central Ltd A report on the European Molecular Biology Laboratory EMBL Oncogenes and Growth Control meeting Heidelberg Germany 17-20 April 2004. The four-day meeting at the European Molecular Biology Laboratory EMBL brought together many of the specialists mainly from Europe and the USA working on cancer and signal transduction. It was the 20th meeting in this series and celebrated 50 years since the discovery of protein kinases by Burnett and Kennedy J Biol Chem 1954 211 969-980 and 25 years since the discovery of tyrosine phosphorylation by Hunter and colleagues Eckhart et al. Cell 1979 18 925933 . Much of the meeting focused on advances obtained using murine models of oncogenesis and this aspect was nicely complemented by more mechanistic talks. Oncogenic signaling One of the most important recent advances in the field of kinase research was the characterization by Tony Hunter Salk Institute for Biological Sciences La Jolla USA and his colleagues of the evolutionary relationships between the 518 mammalian protein kinases encoded in the human genome. The kinases represent the largest family of human enzymes collectively termed the kinome and knowledge about their evolution has greatly facilitated research into these important enzymes. The value of the kinome data was exemplified by the many talks throughout the meeting describing work in which information from Hunter s study was used. In his talk Hunter described the families of human kinases and the domains that they contain. Interestingly 40 .