tailieunhanh - Báo cáo y học: "Can a single model explain both breast cancer and prostate cancer?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Can a single model explain both breast cancer and prostate cancer? | Theoretical Biology and Medical Modelling BioMed Central Research Can a single model explain both breast cancer and prostate cancer A Edward Friedman Open Access Address Department of Mathematics University of Chicago 5734 S. University Avenue Chicago IL 60637 USA Email A Edward Friedman - ed@ Corresponding author Published I August 2007 Received 17 May 2007 Theoretical Biology and Medical Modelling 2007 4 28 doi 1742-4682-4-28 Accepted 1 August 2007 This article is available from http content 4 1 28 2007 Friedman licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Estradiol-Dihydrotestosterone model of prostate cancer PC showed how the interaction of hormones with specific hormone receptors affected apoptosis. The same hormone can produce different effects depending on which hormone receptor it interacts with. Model This model proposes that the first step in the development of most PC and breast cancer BC occurs when aromatase converts testosterone to estradiol E2 . A sufficiently high enough local level of E2 results in telomerase activity. The telomerase activity allows cell division and may lead to BC or PC which will proliferate if the rate of cell division is greater than the rate of cell death. The effect of hormones on their hormone receptors will affect the rate of cell death and determine whether or not the cancer proliferates. Conclusion By minimizing bcl-2 and maximizing apoptotic proteins new systemic treatments for BC and PC can be developed that may be more effective than existing treatments. Background The Estradiol-Dihydrotestosterone E-D model 1 of prostate cancer PC describes how PC works at the level of hormone receptors. In this model no .