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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression

Nuclear actin is involoved in the transcription of all three RNA polymerases, in chromatin remodeling and in the formation of heterogeneous nuclear ribonucleoprotein complexes, as well as in recruitment of the histone modi-fier to the active gene. | ỊFEBS Journal REVIEW ARTICLE Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression Bin Zheng1 Mei Han1 Michel Bernier2 and Jin-kun Wen1 1 Department of Biochemistry and Molecular Biology Hebei MedicalUniversity Shijiazhuang China 2 Laboratory of ClinicalInvestigation NationalInstitute on Aging NationalInstitutes of Health Baltimore MD USA Keywords actin dynamics actin-binding protein chromatin remodeling gene regulation muscle-specific gene nuclear actin nuclear receptor ribonucleoprotein RNA polymerases transcription complex Correspondence J.-k. Wen Department of Biochemistry and Molecular Biology Hebei Medical University No. 361 Zhongshan East Road Shijiazhuang 050017 China Fax 86 311 866 96180 Tel 86 311 862 65563 E-mail wjk@hebmu.edu.cn Received 12 January 2009 revised 20 February 2009 accepted 26 February 2009 doi 10.1111 j.1742-4658.2009.06986.x Nuclear actin is involoved in the transcription of all three RNA polymerases in chromatin remodeling and in the formation of heterogeneous nuclear ribonucleoprotein complexes as well as in recruitment of the histone modifier to the active gene. In addition actin-binding proteins ABPs control actin nucleation bundling filament capping fragmentation and monomer availability in the cytoplasm. In recent years more and more attention has focused on the role of actin and ABPs in the modulation of the subcellular localization of transcriptional regulators. This review focuses on recent developments in the study of transcription and transcriptional regulation by nuclear actin and the regulation of muscle-specific gene expression nuclear receptor and transcription complexes by ABPs. Among the ABPs striated muscle activator of Rho signaling and actin-binding LIM protein regulate actin dynamics and serum response factor-dependent muscle-specific gene expression. Functionally and structurally unrelated cytoplasmic ABPs interact cooperatively with nuclear receptor and regulate its .