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báo cáo hóa học:" Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro | Journal of Translational Medicine BioMed Central Research Stem cells from umbilical cord blood do have myogenic potential with and without differentiation induction in vitro Tatiana Jazedje1 Mariane Secco1 Natássia M Vieira1 Eder Zucconi1 Thomaz R Gollop2 Mariz Vainzof1 and Mayana Zatz 1 Address Department of Biology Human Genome Research Center São Paulo Brazil and 2Fetal Medicine Institute of São Paulo São Paulo Brazil Email Tatiana Jazedje - tatiana@ib.usp.br Mariane Secco - marianesecco@usp.br Natássia M Vieira - natassia@usp.br EderZucconi - ezucconi@usp.br Thomaz R Gollop - trgollop@usp.br MarizVainzof-mvainzof@usp.br MayanaZatz - mayazatz@usp.br Corresponding author Open Access Published 14 January 2009 Received 21 October 2008 Journal of Translational Medicine 2009 7 6 doi l0.ll86 l479-5876-7-6 Accepted I4 January 2009 This article is available from http www.translational-medicine.cOm content 7 1 6 2009 Jazedje et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ The dystrophin gene located at Xp21 codifies dystrophin which is part of a protein complex responsible for the membrane stability of muscle cells. Its absence on muscle causes Duchenne Muscular Dystrophy DMD a severe disorder while a defect of muscle dystrophin causes Becker Muscular Dystrophy DMB a milder disease. The replacement of the defective muscle through stem cells transplantation is a possible future treatment for these patients. Our objective was to analyze the potential of CD34 stem cells from umbilical cord blood to differentiate in muscle cells and express dystrophin in vitro. Protein expression was analyzed by Immunofluorescence Western Blotting WB and Reverse .