tailieunhanh - Báo cáo hóa học: " Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects"

Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects | Mikirova et al. Journal of Translational Medicine 2010 8 34 http content 8 1 34 RESEARCH JOURNAL OF TRANSLATIONAL MEDICINE Open Access Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects Nina A Mikirova 2 2 James A Jackson 2 Ron Hunninghake 2 Julian Kenyon 2 Kyle WH Chan4 c9l h A C A inHlohI ircl 5 11 Rmric lino 6211 Amif l l Pafol7 11 I Iir lo2ỡl p I irpthN 8 11 I cmi 1 h9 11 Cauiy A SVvindlei iuisl 2 Boils Minev 2 Alim N Patel 2 Michael P Murphy 2 Leonard Smith 2 Famela Ramos92112 Thomas E Ichim9211 2 Neil H Riordan 1 2921 021 1 Abstract The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising precli-nical and early clinical data for several degenerative conditions2 this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days I2 22 7 and 14 subsequent to initiation of administration2 which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1 CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors. Introduction Autologous bone marrow derived stem cell therapy has demonstrated benefit in early clinical trials for conditions such as critical limb ischemia 1 2 post infarct remodeling 3 stroke 4 5 and liver failure 6 . While original mechanisms of action were .

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