tailieunhanh - báo cáo hóa học:"Transplantation of selected or transgenic blood stem cells – a future treatment for HIV/AIDS?"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Transplantation of selected or transgenic blood stem cells – a future treatment for HIV/AIDS? | Journal of the International AIDS Society BioMed Central Meeting report Transplantation of selected or transgenic blood stem cells - a future treatment for HIV AIDS Gero Hutter 1 Thomas Schneider2 and Eckhard Thiel1 Open Access Address 1Medical Department III Hematology Oncology Charité Universitatsmedizin Berlin Campus Benjamin Franklin Berlin Germany and 2Medical Department I Gastroenterology Infectious Diseases and Rheumatology Charité Universitatsmedizin Berlin Campus Benjamin Franklin Berlin Germany Email Gero Hutter - Thomas Schneider - Eckhard Thiel - Corresponding author Published 28 June 2009 Received 4 May 2009 Journal of the International AIDS Society 2009 12 10 doi 1758-2652-12-10 Accepted 28 June 2009 This article is available from http content 12 1 10 2009 Hutter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Interaction with the chemokine receptor CCR5 is a necessary precondition for maintaining HIV- 1 infection. Individuals with the CCR5-delta32 deletion who lack this receptor are highly resistant to infection by the most common forms of HIV-1. We recently reported on the successful transplantation in an HIV-1-positive patient of allogeneic stem cells homozygous for the CCR5-delta32 allele which stopped viral replication for more than 27 months without antiretroviral therapy. Here we report on the results of a meeting regarding the potential implications and future directions of stem cell-targeted HIV treatments. The meeting drew together an international panel of hematologists immunologists HIV specialists and representatives from bone marrow donor registries. The meeting came to an .