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Báo cáo y học: " Developmental genomics reaches new heights"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Developmental genomics reaches new heights. | Meeting report Developmental genomics reaches new heights Charalampos Rallis Address Developmental Genetics Laboratory London Research Institute Cancer Research UK London WC2A 3PX UK.Email charalampos.rallis@cancer.org.uk. Published 31 October 2006 Genome Biology 2006 7 329 doi l0.ll86 gb-2006-7-l0-329 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 10 329 2006 BioMed Central Ltd A report on the EMBO SNF symposium The Genomics of Development Arolla Switzerland 21-27 August 2006. The recent EMBO SNF symposium in Switzerland brought together 100 scientists from different disciplines from around the world. The scope of the meeting was to discuss the use of new tools for answering old questions and the review of new techniques and methods from a wide variety of perspectives in the area of developmental genomics. Here I focus on a few presentations that illustrate different approaches such as phenotype-based forward genetic screens and microarrays to the understanding of the functioning of genes and gene networks during development. Forward genetic screening by mutagenesis Almost four years have passed since the Mouse Genome Sequencing consortium published a high-quality draft sequence and analysis of the mouse genome. Nevertheless the functions of an estimated 20 000 genes still remain elusive and in such cases phenotype-based forward genetic screens can be used to assign function to mammalian genes. Kathryn Anderson Memorial Sloan-Kettering Cancer Center New York USA described a genetic screen for recessive mutations that affect morphogenesis and patterning of the mouse embryo. This approach has led to the molecular identification of 22 novel genes. Anderson described the analysis by her group of the mutants wimple and kahloista which reveal the importance of microtubule-and actin-based structures during early development. Wimple mutants exhibit an open brain as a result of the incomplete closure of .