tailieunhanh - Báo cáo y học: " Simplified ontologies allowing comparison of developmental mammalian gene expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Simplified ontologies allowing comparison of developmental mammalian gene expression. | Method Open Access Simplified ontologies allowing comparison of developmental mammalian gene expression Adele Kruger Oliver Hofmann Piero Carnincf Yoshihide Hayashizakf and Winston Hide Addresses South African National Bioinformatics Institute University of the Western Cape Bellville 7535 South Africa. tGenome Exploration Research Group Genome Network Project Core Group RIKEN Genomic Sciences Center GSC RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsurumi-ku Yokohama Kanagawa 230-0045 Japan. Genome Science Laboratory Discovery Research Institute RIKEN Wako Institute 2-1 Hirosawa Wako Saitama 351-0198 Japan. Correspondence Adele Kruger. Email adele@ Published 25 October 2007 Genome Biology 2007 8 R229 doi gb-2007-8- 10-r229 The electronic version of this article is the complete one and can be found online at http 2007 8 10 R229 Received 18 January 2007 Revised 9 February 2007 Accepted 25 October 2007 2007 Kruger et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Model organisms represent an important resource for understanding the fundamental aspects of mammalian biology. Mapping of biological phenomena between model organisms is complex and if it is to be meaningful a simplified representation can be a powerful means for comparison. The Developmental eVOC ontologies presented here are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy. We demonstrate the ontologies by identifying genes showing a bias for developmental brain expression in human and mouse. Background Ontologies and gene expression Biological investigation into mammalian biology employs standardized methods of data annotation by consortia .