tailieunhanh - Báo cáo y học: " Elucidating developmental gene networks"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Elucidating developmental gene networks. | Meeting report Elucidating developmental gene networks Anja Hanisch Annalisa Vezzaro and Charalampos Rallis Addresses Vertebrate Development Laboratory and Developmental Genetics Laboratory London Research Institute Cancer Research UK London WC2A 3PX UK. Correspondence Charalampos Rallis. Email Published 2 June 2008 Genome Biology 2008 9 310 doi gb-2008-9-6-310 The electronic version of this article is the complete one and can be found online at http 2008 9 6 310 2008 BioMed Central Ltd A report on the Joint Meeting of the British Societies for Cell and Developmental Biology Warwick UK 31 March-3 April 2008. This year s annual meeting of the British Societies for Cell and Developmental Biology focused on several aspects of signaling mechanisms and gene and protein networks in relation to cell architecture animal and plant development and evolution. Here we summarize some highlights on morphogen gradients mouse embryo genetic manipulations stem-cell biology and evolution and gene networks during evolution and development. Tracking morphogen gradients One way of establishing positional information within the developing embryo is through the graded distribution of a morphogen a molecule that has the ability to specify cell fate. Gradients of transforming growth factor-P TGF-P family members such as activin are involved in the establishment of the three germ layers endoderm mesoderm and ectoderm . Jim Smith Wellcome Trust Cancer Research UK Gurdon Institute UK described the work of his group to visualize the formation of a gradient of TGF-P signaling in gastrulating embryos. They used the technique of biomole-cular fluorescence complementation BiMC to follow the formation of the heterodimer of the transcription factors Smad2 and Smadq the outcome of TGF-P-type signaling. The amino-terminal half of the fluorescent protein Venus is fused to Smad2 and the carboxy-terminal half of the protein is fused to Smadq. On