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Báo cáo y học: "Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana. | Research Open Access Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana Tineke Casneuf Stefanie De Bodt Jeroen Raes Steven Maere and Yves Van de Peer Addresses Department of Plant Systems Biology Flanders Interuniversity Institute for Biotechnology VIB Ghent University Technologiepark 927 B-9052 Ghent Belgium. ỶComputational and Structural Biology Unit European Molecular Biology Laboratory EMBL Meyerhofstrasse D-69117 Heidelberg Germany. Correspondence Yves Van de Peer. Email yves.vandepeer@psb.ugent.be Published 20 February 2006 Genome Biology 2006 7 R13 doi 10.1 186 gb-2006-7-2-r13 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 2 R13 Received 26 September 2005 Revised 20 December 2005 Accepted 25 January 2006 2006 Casneuf et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Genome analyses have revealed that gene duplication in plants is rampant. Furthermore many of the duplicated genes seem to have been created through ancient genomewide duplication events. Recently we have shown that gene loss is strikingly different for large- and small-scale duplication events and highly biased towards the functional class to which a gene belongs. Here we study the expression divergence of genes that were created during large- and small-scale gene duplication events by means of microarray data and investigate both the influence of the origin mode of duplication and the function of the duplicated genes on expression divergence. Results Duplicates that have been created by large-scale duplication events and that can still be found in duplicated segments have expression .