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Báo cáo y học: "ystems biology: where it’s at in 2005"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Systems biology: where it’s at in 2005 | Meeting report Systems biology where it s at in 2005 Ben Lehner Julia Tischler and Andrew G Fraser Address The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Correspondence Andrew G Fraser. E-mail agf@sanger.ac.uk Published I August 2005 Genome Biology 2005 6 338 doi I0.II86 gb-2005-6-8-338 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 8 338 2005 BioMed Central Ltd A report on the joint Keystone Symposia on Systems and Biology and Proteomics and Bioinformatics Keystone USA 8-13 April 2005. Recent developments in high-throughput biology mean that we can now study the functions of hundreds or thousands of genes in parallel. Systems biology is the discipline that aims to make sense of the resulting deluge of data in order to provide a comprehensive molecular description of biological processes. A recent joint Keystone meeting provided an opportunity for reflection on the current state of play and future directions for systems biology. Mapping networks Currently one of the largest subsets of systems biologists are the molecular cartographers - researchers who are systematically mapping huge datasets of for example proteinprotein or protein-DNA interactions. Although generating such networks de novo is extremely important another vital aspect of network construction is the incorporation of data already available from the scientific literature. Mike Tyers University of Toronto Canada described how a group of about ten people were able to extract about 30 000 proteinprotein and 11 000 genetic interactions for the yeast Saccha-romyces cerevisiae from the literature in a period of about ten weeks and he strongly encouraged other communities to engage in similar activities. Analysis of the resulting dataset revealed some interesting differences between interaction maps derived from the literature and maps derived from high-throughput screens. For example whereas