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Báo cáo y học: "Temporal and spatial patterning of an organ by a single transcription factor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Temporal and spatial patterning of an organ by a single transcription factor. | Minireview Temporal and spatial patterning of an organ by a single transcription factor Diya Banerjee and Frank J Slack Address Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06520 USA. Correspondence Frank J Slack. E-mail frank.slack@yale.edu Published 25 January 2005 Genome Biology 2005 6 205 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 2 205 2005 BioMed Central Ltd Abstract During the formation of animal organs a single regulatory factor can control the majority of cellfate decisions but the mechanisms by which this occurs are poorly understood. One such regulator the nematode transcription factor PHA-4 functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx. Animal organs are composed of multiple varied tissues which must form coordinately in the right place and in the right sequence during development 1 2 . A process as complex as organ formation requires precision and selectivity of gene expression on a number of spatial and temporal levels. Certain genes are expressed in all of the cells that will constitute the particular organ thus conferring an organ identity upon a field of cells while other genes are expressed specifically in subsets of cells thus allowing differentiation of tissue types within the organ. Both of these kinds of geneexpression program in organogenesis are coordinated and regulated temporally so that the expression patterns follow a precise sequence. It might be expected that the various levels of control would require a large number of transcriptional regulators but an astonishing finding from more than a decade of research is that complex patterns of cellfate determination and differentiation can be regulated by single selector genes 3 4 . A selector gene encodes a gene regulator typically a transcription factor which autonomously .