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Báo cáo y học: "Tetraodon genome confirms Takifugu findings: most fish are ancient polyploids"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Tetraodon genome confirms Takifugu findings: most fish are ancient polyploids. | Minireview Tetraodon genome confirms Takifugu findings most fish are ancient polyploids Yves Van de Peer Address Bioinformatics and Evolutionary Genomics Vlaams Interuniversitair Instituut voor Biotechnologie VIB Ghent University Technologiepark 927 B-9052 Ghent Belgium. E-mail yves.vandepeer@psb.ugent.be Published 25 November 2004 Genome Biology 2004 5 250 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 12 250 2004 BioMed Central Ltd Abstract An evolutionary hypothesis suggested by studies of the genome of the tiger pufferfish Takifugu rubripes has now been confirmed by comparison with the genome of a close relative the spotted green pufferfish Tetraodon nigroviridis. Ray-finned fish underwent a whole-genome duplication some 350 million years ago that might explain their evolutionary success. In 1993 Sydney Brenner and colleagues 1 proposed sequencing the pufferfish genome as a cost-effective way to identify and characterize human genes. The genome of the pufferfish is only about one-eighth of the size of that of human but was expected to contain a similar gene repertoire. Ten years later not only has a draft genome sequence been released for Ta.kifu.gu rubripes Fugu also known as the Japanese or tiger pufferfish 2 but also for Tetraodon nigroviridis green spotted pufferfish 3 a close relative that diverged from Takifugu 18-30 million years ago Mya . By comparing the two pufferfish genomes with that of human several hundred novel human genes have already been uncovered as was predicted by Brenner and colleagues 1 . But the pufferfish genome sequencing projects have also yielded a surprising finding ray-finned fish Actinopterygii such as pufferfish might have more genes than lobe-finned fish coelacanths and lungfish and land vertebrates because of additional gene-duplication events 4 . The recent release of the Tetraodon genome sequence 3 provides overwhelming evidence that a genome-duplication .