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Báo cáo y học: "Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice. | Open Access Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice Jonathan M Mudge Stuart D Armstrong Karen McLaren Robert J Beynon Jane L Hurst Christine Nicholson Duncan H Robertson Laurens G Wilming and Jennifer L Harrow Addresses Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Proteomics and Functional Genomics Group Department of Veterinary Preclinical Science University of Liverpool Crown Street and Brownlow Hill Liverpool L69 7ZJ UK. Mammalian Behavior and Evolution Group Department of Veterinary Preclinical Science University of Liverpool Leahurst Neston Ch64 7TE UK. Correspondence Jonathan M Mudge. Email jm12@sanger.ac.uk Published 28 May 2008 Genome Biology 2008 9 R91 doi 10.ll86 gb-2008-9-5-r9l The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 5 R9l Received 23 January 2008 Revised 7 April 2008 Accepted 28 May 2008 2008 Mudge et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The major urinary proteins MUPs of Mus musculus domesticus are deposited in urine in large quantities where they bind and release pheromones and also provide an individual recognition signal via their phenotypic polymorphism. Whilst important information about MUP functionality has been gained in recent years the gene cluster is poorly studied in terms of structure genic polymorphism and evolution. Results We combine targeted sequencing manual genome annotation and phylogenetic analysis to compare the Mup clusters of C57BL 6J and 129 strains of mice. We describe organizational heterogeneity within both clusters a central .