tailieunhanh - Báo cáo y học: " Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation | Theoretical Biology and Medical Modelling BioMed Central Open Access Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation Gary An Address Department of Surgery Northwestern University Feinberg School of Medicine Chicago IL USA Email Gary An - docgca@ Published 27 May 2008 Received 3 October 2007 Theoretical Biology and Medical Modelling 2008 5 11 doi 1742-4682-5-11 Accepted 27 May 2008 This article is available from http content 5 1 1 1 2008 An licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background One of the greatest challenges facing biomedical research is the integration and sharing of vast amounts of information not only for individual researchers but also for the community at large. Agent Based Modeling ABM can provide a means of addressing this challenge via a unifying translational architecture for dynamic knowledge representation. This paper presents a series of linked ABMs representing multiple levels of biological organization. They are intended to translate the knowledge derived from in vitro models of acute inflammation to clinically relevant phenomenon such as multiple organ failure. Results and Discussion ABM development followed a sequence starting with relatively direct translation from in-vitro derived rules into a cell-as-agent level ABM leading on to concatenated ABMs into multi-tissue models eventually resulting in topologically linked aggregate multi-tissue ABMs modeling organ-organ crosstalk. As an underlying design principle organs were considered to be functionally composed of an epithelial surface which determined organ integrity and an endothelial blood interface representing the .